An APC Mutation in a Large Chinese Kindred With Familial Adenomatous Polyposis Was Identified Using Both Next Generation Sequencing and Simple STR Marker Haplotypes

An APC Mutation in a Large Chinese Kindred With Familial Adenomatous Polyposis Was Identified Using Both Next Generation Sequencing and Simple STR Marker Haplotypes

BackgroundFamilial adenomatous polyposis (FAP) is an autosomal dominant disorder characterized primarily by the development of numerous adenomatous polyps in the colon and a high risk for colorectal cancer. FAP is caused by germline mutations of the adenomatous polyposis coli (APC) gene. The proband...

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Bibliographic Details
Main Authors: Qitao Zhan, Liya Wang, Xiangrong Xu, Yan Sun, Lejun Li, Xuchen Qi, Feng Chen, Xiaoming Wei, Michael L. Raff, Ping Yu, Fan Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Genetics
Subjects:
familial adenomatous polyposis
APC gene
STR marker
next generation sequencing
mutation
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00191/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2020.00191/full

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