Immune signatures of the POLE mutation in endometrial carcinomas: a systematic study based on TCGA data and clinical cohort validation

Immune signatures of the POLE mutation in endometrial carcinomas: a systematic study based on TCGA data and clinical cohort validation

BackgroundPOLE is a critical biomarker for endometrial cancer (ECs) prognosis and therapeutic decision. However, the immune infiltration and immunotherapy-related gene expression in the tumor microenvironment (TME) of POLE-mutated ECs remain unresolved.MethodsThe TCGA database was used to characteri...

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Bibliographic Details
Main Authors: Tieyan Wang, Dan Yu, Juanjuan Wang, Ningning Zhu, Xian-bin Tang, Xiuwen Chen, Xiao-min Su, Yu-gang Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Oncology
Subjects:
endometrial carcinoma
POLE mutation
immune signatures
tumor immune microenvironment
immune infiltration
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1250558/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1250558/full

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