Association between hypertension and neurovascular inflammation in both normal-appearing white matter and white matter hyperintensities

Association between hypertension and neurovascular inflammation in both normal-appearing white matter and white matter hyperintensities

Abstract The major vascular cause of dementia is cerebral small vessel disease (SVD), including white matter hyperintensities (WMH) amongst others. While the underlying pathology of SVD remains unclear, chronic hypertension and neuroinflammation are recognized as important risk factors for SVD and f...

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Bibliographic Details
Main Authors: Gemma Solé-Guardia, Emma Custers, Arthur de Lange, Elyne Clijncke, Bram Geenen, Jose Gutierrez, Benno Küsters, Jurgen A. H. R. Claassen, Frank-Erik de Leeuw, Maximilian Wiesmann, Amanda J. Kiliaan
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Acta Neuropathologica Communications
Subjects:
Small vessel disease
Hypertension
White matter hyperintensities
Normal-appearing white matter
Post-mortem MRI
Inflammation
Online Access:https://doi.org/10.1186/s40478-022-01497-3

Internet

https://doi.org/10.1186/s40478-022-01497-3

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