Design and characterization of mouse IgG1 and IgG2a bispecific antibodies for use in syngeneic models

Design and characterization of mouse IgG1 and IgG2a bispecific antibodies for use in syngeneic models

The development of antibody therapeutics relies on animal models that accurately recapitulate disease biology. Syngeneic mouse models are increasingly used with new molecules to capture the biology of complex cancers and disease states, and to provide insight into the role of the immune system. The...

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Bibliographic Details
Main Authors: Feng Wang, Jordan C. Tsai, Jonathan H. Davis, Bryant Chau, Jia Dong, Sean M. West, Jason M. Hogan, Matthew L. Wheeler, Christine Bee, Winse Morishige, Thomas Cayton, Donata David-brown, Chengyue Zhang, Alexander Kozhich, Tim Sproul, Gavin Dollinger, Arvind Rajpal, Pavel Strop
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:mAbs
Subjects:
Mouse bispecific antibodies
electrostatic steering
inter-chain disulfide bond shifting
co-expression
T-cell engaging bispecific antibody
syngeneic mouse model
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2019.1685350

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https://www.tandfonline.com/doi/10.1080/19420862.2019.1685350

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