Integrated study of systemic and local airway transcriptomes in asthma reveals causal mediation of systemic effects by airway key drivers

Abstract Background Systemic and local profiles have each been associated with asthma, but parsing causal relationships between system-wide and airway-specific processes can be challenging. We sought to investigate systemic and airway processes in asthma and their causal relationships. Methods Three...

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Bibliographic Details
Main Authors: Lingdi Zhang, Yoojin Chun, Haritz Irizar, Zoe Arditi, Galina Grishina, Alexander Grishin, Alfin Vicencio, Supinda Bunyavanich
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Genome Medicine
Subjects:
Online Access:https://doi.org/10.1186/s13073-023-01222-2