Botulinum Neurotoxin Chimeras Suppress Stimulation by Capsaicin of Rat Trigeminal Sensory Neurons In Vivo and In Vitro

Botulinum Neurotoxin Chimeras Suppress Stimulation by Capsaicin of Rat Trigeminal Sensory Neurons In Vivo and In Vitro

Chimeras of botulinum neurotoxin (BoNT) serotype A (/A) combined with /E protease might possess improved analgesic properties relative to either parent, due to inheriting the sensory neurotropism of the former with more extensive disabling of SNAP-25 from the latter. Hence, fusions of /E protease li...

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Bibliographic Details
Main Authors: Caren Antoniazzi, Mariia Belinskaia, Tomas Zurawski, Seshu Kumar Kaza, J. Oliver Dolly, Gary W. Lawrence
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Toxins
Subjects:
botulinum neurotoxins
exocytosis
calcitonin gene-related peptide
migraine
nociception
trigeminal ganglion
Online Access:https://www.mdpi.com/2072-6651/14/2/116

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https://www.mdpi.com/2072-6651/14/2/116

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