Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by γ-secretase

Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by γ-secretase

Deuterium/hydrogen exchange shows that conformational flexibility of the hybrid transmembrane domains (TMD) of amyloid precursor proteins plays a role in TMD cleavability by γ-secretase in vitro and in cellulo.

Bibliographic Details
Main Authors: Nadine T. Werner, Philipp Högel, Gökhan Güner, Walter Stelzer, Manfred Wozny, Marlene Aßfalg, Stefan F. Lichtenthaler, Harald Steiner, Dieter Langosch
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-04470-5

Internet

https://doi.org/10.1038/s42003-023-04470-5

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