Nicotinic Acetylcholine Receptors Are Novel Targets of APETx-like Toxins from the Sea Anemone <i>Heteractis magnifica</i>

Nicotinic Acetylcholine Receptors Are Novel Targets of APETx-like Toxins from the Sea Anemone <i>Heteractis magnifica</i>

The nicotinic acetylcholine receptors (nAChRs) are prototypical ligand-gated ion channels, provide cholinergic signaling, and are modulated by various venom toxins and drugs in addition to neurotransmitters. Here, four APETx-like toxins, including two new toxins, named Hmg 1b-2 Met<sub>ox</...

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Bibliographic Details
Main Authors: Rimma S. Kalina, Igor E. Kasheverov, Sergey G. Koshelev, Oksana V. Sintsova, Steve Peigneur, Ernesto Lopes Pinheiro-Junior, Roman S. Popov, Victoria E. Chausova, Margarita M. Monastyrnaya, Pavel S. Dmitrenok, Marina P. Isaeva, Jan Tytgat, Sergey A. Kozlov, Emma P. Kozlovskaya, Elena V. Leychenko, Irina N. Gladkikh
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Toxins
Subjects:
sea anemones
phylogeny
APETx-like toxins
nicotinic acetylcholine receptors
acid-sensing ion channels
Online Access:https://www.mdpi.com/2072-6651/14/10/697

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https://www.mdpi.com/2072-6651/14/10/697

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