RTP801/REDD1 Is Involved in Neuroinflammation and Modulates Cognitive Dysfunction in Huntington’s Disease

RTP801/REDD1 Is Involved in Neuroinflammation and Modulates Cognitive Dysfunction in Huntington’s Disease

RTP801/REDD1 is a stress-regulated protein whose levels are increased in several neurodegenerative diseases such as Parkinson’s, Alzheimer’s, and Huntington’s diseases (HD). RTP801 downregulation ameliorates behavioral abnormalities in several mouse models of these disorders. In HD, RTP801 mediates...

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Bibliographic Details
Main Authors: Leticia Pérez-Sisqués, Júlia Solana-Balaguer, Genís Campoy-Campos, Núria Martín-Flores, Anna Sancho-Balsells, Marcel Vives-Isern, Ferran Soler-Palazón, Marta Garcia-Forn, Mercè Masana, Jordi Alberch, Esther Pérez-Navarro, Albert Giralt, Cristina Malagelada
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Biomolecules
Subjects:
RTP801/REDD1
Huntington’s disease
neuroinflammation
hippocampus
cognitive dysfunction
Online Access:https://www.mdpi.com/2218-273X/12/1/34

Internet

https://www.mdpi.com/2218-273X/12/1/34

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