Identification and Validation of an <i>Aspergillus nidulans</i> Secondary Metabolite Derivative as an Inhibitor of the Musashi-RNA Interaction

Identification and Validation of an <i>Aspergillus nidulans</i> Secondary Metabolite Derivative as an Inhibitor of the Musashi-RNA Interaction

RNA-binding protein Musashi-1 (MSI1) is a key regulator of several stem cell populations. MSI1 is involved in tumor proliferation and maintenance, and it regulates target mRNAs at the translational level. The known mRNA targets of MSI1 include <i>Numb</i>, <i>APC</i>, and <...

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Bibliographic Details
Main Authors: Lan Lan, Jiajun Liu, Minli Xing, Amber R. Smith, Jinan Wang, Xiaoqing Wu, Carl Appelman, Ke Li, Anuradha Roy, Ragul Gowthaman, John Karanicolas, Amber D. Somoza, Clay C. C. Wang, Yinglong Miao, Roberto De Guzman, Berl R. Oakley, Kristi L. Neufeld, Liang Xu
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
RNA-binding proteins
Musashi
drug discovery
Notch signaling
Wnt signaling
cancer therapy
Online Access:https://www.mdpi.com/2072-6694/12/8/2221

Internet

https://www.mdpi.com/2072-6694/12/8/2221

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