Tumor Microenvironment Responsive CD8+ T Cells and Myeloid‐Derived Suppressor Cells to Trigger CD73 Inhibitor AB680‐Based Synergistic Therapy for Pancreatic Cancer

Tumor Microenvironment Responsive CD8+ T Cells and Myeloid‐Derived Suppressor Cells to Trigger CD73 Inhibitor AB680‐Based Synergistic Therapy for Pancreatic Cancer

Abstract CD73 plays a critical role in the pathogenesis and immune escape in pancreatic ductal adenocarcinoma (PDAC). AB680, an exceptionally potent and selective inhibitor of CD73, is administered in an early clinical trial, in conjunction with gemcitabine and anti‐PD‐1 therapy, for the treatment o...

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Bibliographic Details
Main Authors: Qiangda Chen, Hanlin Yin, Junyi He, Yuqi Xie, Wenquan Wang, Huaxiang Xu, Lei Zhang, Chenye Shi, Jun Yu, Wenchuan Wu, Liang Liu, Ning Pu, Wenhui Lou
Format: Article
Language:English
Published: Wiley 2023-11-01
Series:Advanced Science
Subjects:
CD73
AB680
combination therapy
pancreatic cancer
Online Access:https://doi.org/10.1002/advs.202302498

Internet

https://doi.org/10.1002/advs.202302498

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