Bookend: precise transcript reconstruction with end-guided assembly

Abstract We developed Bookend, a package for transcript assembly that incorporates data from different RNA-seq techniques, with a focus on identifying and utilizing RNA 5′ and 3′ ends. We demonstrate that correct identification of transcript start and end sites is essential for precise full-length t...

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Bibliographic Details
Main Authors: Michael A. Schon, Stefan Lutzmayer, Falko Hofmann, Michael D. Nodine
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Genome Biology
Subjects:
Online Access:https://doi.org/10.1186/s13059-022-02700-3