Bcl-2 phosphorylation in the BH4 domain precedes caspase-3 activation and cell death after neonatal cerebral hypoxic–ischemic injury

Bcl-2 phosphorylation in the BH4 domain precedes caspase-3 activation and cell death after neonatal cerebral hypoxic–ischemic injury

To date, there are very few in vivo studies addressing the role of Bcl-2 phosphorylation. In a model of neonatal hypoxic–ischemic (HI) brain injury, we characterized the spatial and temporal phosphorylation of Bcl-2 at serine-24 (PS24-Bcl-2), using a site-specific antibody. Very few cells positive f...

Full description

Bibliographic Details
Main Authors: Ulrika Hallin, Eisaku Kondo, Yasuhiko Ozaki, Henrik Hagberg, Futoshi Shibasaki, Klas Blomgren
Format: Article
Language:English
Published: Elsevier 2006-03-01
Series:Neurobiology of Disease
Subjects:
Neonatal brain
Hypoxia–ischemia
Asphyxia
Apoptosis
Mitochondria
Bcl-2
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105002354

Internet

http://www.sciencedirect.com/science/article/pii/S0969996105002354

Similar Items