A randomised placebo-controlled trial investigating efficacy and mechanisms of low-dose intradermal allergen immunotherapy in treatment of seasonal allergic rhinitis

A randomised placebo-controlled trial investigating efficacy and mechanisms of low-dose intradermal allergen immunotherapy in treatment of seasonal allergic rhinitis

Background: We previously reported that repeated low-dose grass pollen intradermal allergen injection suppresses allergen-induced cutaneous late-phase responses, comparable with conventional high-dose subcutaneous and sublingual immunotherapy. Objective: To evaluate the efficacy and mechanism of gra...

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Bibliographic Details
Main Authors: Anna Slovick, Abdel Douiri, Rachel Muir, Andrea Guerra, Konstantinos Tsioulos, Evie Haye, Emily PS Lam, Joanna Kelly, Janet L Peacock, Sun Ying, Mohamed H Shamji, David J Cousins, Stephen R Durham, Stephen J Till
Format: Article
Language:English
Published: NIHR Journals Library 2016-12-01
Series:Efficacy and Mechanism Evaluation
Subjects:
allergy
vaccine
clinical trial
hay fever
allergic rhinitis
randomised
double-blind
placebo
grass pollen
intradermal
injection
wheal
histamine
timothy grass
phleum pratense
immunology
immunotherapy
Online Access:https://doi.org/10.3310/eme03100

Internet

https://doi.org/10.3310/eme03100

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