Optimization of universal allogeneic CAR-T cells combining CRISPR and transposon-based technologies for treatment of acute myeloid leukemia

Optimization of universal allogeneic CAR-T cells combining CRISPR and transposon-based technologies for treatment of acute myeloid leukemia

Despite the potential of CAR-T therapies for hematological malignancies, their efficacy in patients with relapse and refractory Acute Myeloid Leukemia has been limited. The aim of our study has been to develop and manufacture a CAR-T cell product that addresses some of the current limitations. We in...

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Bibliographic Details
Main Authors: Cristina Calviño, Candela Ceballos, Ana Alfonso, Patricia Jauregui, Maria E. Calleja-Cervantes, Patxi San Martin-Uriz, Paula Rodriguez-Marquez, Angel Martin-Mallo, Elena Iglesias, Gloria Abizanda, Saray Rodriguez-Diaz, Rebeca Martinez-Turrillas, Jorge Illarramendi, Maria C. Viguria, Margarita Redondo, Jose Rifon, Sara Villar, Juan J. Lasarte, Susana Inoges, Ascension Lopez-Diaz de Cerio, Mikel Hernaez, Felipe Prosper, Juan R. Rodriguez-Madoz
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
allogeneic CAR-T
CRISPR
transposon
AML
transcriptomics (RNA sequencing)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1270843/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1270843/full

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