Structural Studies of <i>Klebsiella pneumoniae</i> Fosfomycin-Resistance Protein and Its Application for the Development of an Optical Biosensor for Fosfomycin Determination

Structural Studies of <i>Klebsiella pneumoniae</i> Fosfomycin-Resistance Protein and Its Application for the Development of an Optical Biosensor for Fosfomycin Determination

Fosfomycin-resistance proteins (FosAs) are dimeric metal-dependent glutathione transferases that conjugate the antibiotic fosfomycin (Fos) to the tripeptide glutathione (γ-Glu-Cys-Gly, GSH), rendering it inactive. In the present study, we reported a comparative analysis of the functional features of...

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Bibliographic Details
Main Authors: Christina Varotsou, Farid Ataya, Anastassios C. Papageorgiou, Nikolaos E. Labrou
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
antibiotic resistance
fosfomycin-resistance protein
<i>Klebsiella pneumoniae</i>
<i>Pseudomonas aeruginosa</i>
glutathione
fosfomycin
Online Access:https://www.mdpi.com/1422-0067/25/1/85

Internet

https://www.mdpi.com/1422-0067/25/1/85

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