The Immunoregulatory and Regenerative Potential of Activated Human Stem Cell Secretome Mitigates Acute-on-Chronic Liver Failure in a Rat Model

The Immunoregulatory and Regenerative Potential of Activated Human Stem Cell Secretome Mitigates Acute-on-Chronic Liver Failure in a Rat Model

Acute-on-chronic liver failure (ACLF) is a syndrome marked by sudden liver function decline and multiorgan failure, predominantly acute kidney injury (AKY), in patients with chronic liver disease. Unregulated inflammation is a hallmark of ACLF; however, the key drivers of ACLF are not fully understo...

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Bibliographic Details
Main Authors: Barbara Cuadra, Veronica Silva, Ya-Lin Huang, Yael Diaz, Claudio Rivas, Cristobal Molina, Valeska Simon, Maria Rosa Bono, Bernardo Morales, Mario Rosemblatt, Sebastian Silva, Rodrigo Acuña, Fernando Ezquer, Marcelo Ezquer
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
mesenchymal stem cells
in vitro preconditioning
acute-on-chronic liver failure
secretome
multiorgan failure
Online Access:https://www.mdpi.com/1422-0067/25/4/2073

Internet

https://www.mdpi.com/1422-0067/25/4/2073

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