Vaccine co-display of CSP and Pfs230 on liposomes targeting two Plasmodium falciparum differentiation stages

Vaccine co-display of CSP and Pfs230 on liposomes targeting two Plasmodium falciparum differentiation stages

Co-display of two P. falciparum malaria vaccine antigens (Pfs230D1+ and CSP) on the surface of immunogenic liposomes results in functional immune responses upon immunization of mice and rabbits. Combining both antigens produces immune responses that both block transmission and prevent infection.

Bibliographic Details
Main Authors: Wei-Chiao Huang, Moustafa T. Mabrouk, Luwen Zhou, Minami Baba, Mayumi Tachibana, Motomi Torii, Eizo Takashima, Emily Locke, Jordan Plieskatt, C. Richter King, Camila H. Coelho, Patrick E. Duffy, Carole Long, Takafumi Tsuboi, Kazutoyo Miura, Yimin Wu, Tomoko Ishino, Jonathan F. Lovell
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03688-z

Internet

https://doi.org/10.1038/s42003-022-03688-z

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