Control of APOBEC3B induction and cccDNA decay by NF-κB and miR-138-5p

Control of APOBEC3B induction and cccDNA decay by NF-κB and miR-138-5p

Background & Aims: Immune-mediated induction of cytidine deaminase APOBEC3B (A3B) expression leads to HBV covalently closed circular DNA (cccDNA) decay. Here, we aimed to decipher the signalling pathway(s) and regulatory mechanism(s) involved in A3B induction and related HBV control. Methods...

Full description

Bibliographic Details
Main Authors: Suzanne Faure-Dupuy, Tobias Riedl, Maude Rolland, Zoheir Hizir, Florian Reisinger, Katharina Neuhaus, Svenja Schuehle, Caroline Remouchamps, Nicolas Gillet, Maximilian Schönung, Mira Stadler, Jochen Wettengel, Romain Barnault, Romain Parent, Linda Christina Schuster, Rayan Farhat, Sandra Prokosch, Corinna Leuchtenberger, Rupert Öllinger, Thomas Engleitner, Karsten Rippe, Roland Rad, Kristian Unger, Darjus Tscharahganeh, Daniel B. Lipka, Ulrike Protzer, David Durantel, Julie Lucifora, Emmanuel Dejardin, Mathias Heikenwälder
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:JHEP Reports
Subjects:
APOBEC3B
Hepatitis B virus
NF-κB
miRNA
cccDNA
HBx
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555921001300

Internet

http://www.sciencedirect.com/science/article/pii/S2589555921001300

Similar Items