Regression of Human Breast Carcinoma in Nude Mice after Ad<i>sflt</i> Gene Therapy Is Mediated by Tumor Vascular Endothelial Cell Apoptosis

Two vascular endothelial growth factor (VEGF) receptors, FLT-1 and KDR, are expressed preferentially in proliferating endothelium. There is increasing evidence that recombinant, soluble VEGF receptor domains interfering with VEGF signaling may inhibit in vivo neoangiogenesis, tumor growth and metast...

Full description

Bibliographic Details
Main Authors: Angelina Felici, Donald P. Bottaro, Antonella Mangoni, Petra Reusch, Dieter Marmé, Imre Kovesdi, Dinuka M. De Silva, Young H. Lee, Maurizio C. Capogrossi, Judith Mühlhauser
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cancers
Subjects:
Online Access:https://www.mdpi.com/2072-6694/14/24/6175