B-cell Receptor Signaling Induced Metabolic Alterations in Chronic Lymphocytic Leukemia Can Be Partially Bypassed by TP53 Abnormalities

It has been unclear what role metabolism is playing in the pathophysiology of chronic lymphocytic leukemia (CLL). One reason is that the study of CLL metabolism is challenging due to the resting nature of circulating CLL cells. Also, it is not clear if any of the genomic aberrations observed in this...

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Bibliographic Details
Main Authors: Katarina Kluckova, Andrew J. Clear, Annalisa D’Avola, Laura Z. Rassenti, Thomas J. Kipps, John G. Gribben, John C. Riches
Format: Article
Language:English
Published: Wiley 2022-06-01
Series:HemaSphere
Online Access:http://journals.lww.com/10.1097/HS9.0000000000000722