The Elephant and the Blind Men: Making Sense of PARP Inhibitors in Homologous Recombination Deficient Tumor Cells

The Elephant and the Blind Men: Making Sense of PARP Inhibitors in Homologous Recombination Deficient Tumor Cells

Poly(ADP-ribose) polymerase 1 (PARP1) is an important component of the base excision repair (BER) pathway as well as a regulator of homologous recombination (HR) and nonhomologous end-joining (NHEJ). Previous studies have demonstrated that treatment of HR-deficient cells with PARP inhibitors results...

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Bibliographic Details
Main Authors: Silvana eDe Lorenzo, Anand ePatel, Rachel eHurley, Scott H. Kaufmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Oncology
Subjects:
Homologous Recombination
breast cancer
ovarian cancer
BRCA1
BRCA2
synthetic lethality
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00228/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00228/full

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