The oncogenic fusion protein TAZ::CAMTA1 promotes genomic instability and senescence through hypertranscription
Abstract TAZ::CAMTA1 is a fusion protein found in over 90% of Epithelioid Hemangioendothelioma (EHE), a rare vascular sarcoma with an unpredictable disease course. To date, how TAZ::CAMTA1 initiates tumour formation remains unexplained. To study the oncogenic mechanism leading to EHE initiation, we...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-11-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-05540-4 |