Regulatory consequences of neuronal ELAV-like protein binding to coding and non-coding RNAs in human brain

Regulatory consequences of neuronal ELAV-like protein binding to coding and non-coding RNAs in human brain

Neuronal ELAV-like (nELAVL) RNA binding proteins have been linked to numerous neurological disorders. We performed crosslinking-immunoprecipitation and RNAseq on human brain, and identified nELAVL binding sites on 8681 transcripts. Using knockout mice and RNAi in human neuroblastoma cells, we showed...

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Bibliographic Details
Main Authors: Claudia Scheckel, Elodie Drapeau, Maria A Frias, Christopher Y Park, John Fak, Ilana Zucker-Scharff, Yan Kou, Vahram Haroutunian, Avi Ma'ayan, Joseph D Buxbaum, Robert B Darnell
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-02-01
Series:eLife
Subjects:
alternative splicing
alzheimer's disease
nELAVL
mRNA stability
Y RNA
noncoding RNA
Online Access:https://elifesciences.org/articles/10421

Internet

https://elifesciences.org/articles/10421

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