Systems biology approach to identify gene network signatures for colorectal cancer

Systems biology approach to identify gene network signatures for colorectal cancer

In this work, we integrated prior knowledge from GWAS studies or gene signatures (curated gene sets from MSigDB and/or GeneSigDB), gene set enrichment analysis (GSEA), and gene/protein network modeling together to identify gene network signatures from microarray data. We demonstrated how to apply th...

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Bibliographic Details
Main Authors: Madhankumar eSonachalam, Jeffrey eShen, Hui eHuang, Xiaogang eWu
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-05-01
Series:Frontiers in Genetics
Subjects:
Microarray Analysis
colorectal cancer
network biology
gene set enrichment analysis
gene expression signatures
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00080/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00080/full

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