High SARS-CoV-2 tropism and activation of immune cells in the testes of non-vaccinated deceased COVID-19 patients

High SARS-CoV-2 tropism and activation of immune cells in the testes of non-vaccinated deceased COVID-19 patients

Abstract Background Cellular entry of SARS-CoV-2 has been shown to rely on angiotensin-converting enzyme 2 (ACE2) receptors, whose expression in the testis is among the highest in the body. Additionally, the risk of mortality seems higher among male COVID-19 patients, and though much has been publis...

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Main Authors: Guilherme M. J. Costa, Samyra M. S. N. Lacerda, André F. A. Figueiredo, Natália T. Wnuk, Marcos R. G. Brener, Lídia M. Andrade, Gabriel H. Campolina-Silva, Andrea Kauffmann-Zeh, Lucila G. G. Pacifico, Alice F. Versiani, Maísa M. Antunes, Fernanda R. Souza, Geovanni D. Cassali, André L. Caldeira-Brant, Hélio Chiarini-Garcia, Fernanda G. de Souza, Vivian V. Costa, Flavio G. da Fonseca, Maurício L. Nogueira, Guilherme R. F. Campos, Lucas M. Kangussu, Estefânia M. N. Martins, Loudiana M. Antonio, Cintia Bittar, Paula Rahal, Renato S. Aguiar, Bárbara P. Mendes, Marcela S. Procópio, Thiago P. Furtado, Yuri L. Guimaraes, Gustavo B. Menezes, Ana Martinez-Marchal, Kyle E. Orwig, Miguel Brieño-Enríquez, Marcelo H. Furtado
Format: Article
Language:English
Published: BMC 2023-02-01
Series:BMC Biology
Subjects:
SARS-CoV-2 replication
Macrophages
Spermatogonia
Sertoli cell
Leydig cell
Renin-angiotensin system
Online Access:https://doi.org/10.1186/s12915-022-01497-8

Internet

https://doi.org/10.1186/s12915-022-01497-8

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