Facile metabolic reprogramming distinguishes mycobacterial adaptation to hypoxia and starvation: ketosis drives starvation-induced persistence in M. bovis BCG

Facile metabolic reprogramming distinguishes mycobacterial adaptation to hypoxia and starvation: ketosis drives starvation-induced persistence in M. bovis BCG

Abstract Mycobacteria adapt to infection stresses by entering a reversible non-replicating persistence (NRP) with slow or no cell growth and broad antimicrobial tolerance. Hypoxia and nutrient deprivation are two well-studied stresses commonly used to model the NRP, yet little is known about the mol...

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Bibliographic Details
Main Authors: Nick K. Davis, Yok Hian Chionh, Megan E. McBee, Fabian Hia, Duanduan Ma, Liang Cui, Mariam Lucila Sharaf, Weiling Maggie Cai, Watthanachai Jumpathong, Stuart S. Levine, Sylvie Alonso, Peter C. Dedon
Format: Article
Language:English
Published: Nature Portfolio 2024-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-06562-2

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https://doi.org/10.1038/s42003-024-06562-2

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