Integrating the skin and blood transcriptomes and serum proteome in hidradenitis suppurativa reveals complement dysregulation and a plasma cell signature.

Integrating the skin and blood transcriptomes and serum proteome in hidradenitis suppurativa reveals complement dysregulation and a plasma cell signature.

Hidradenitis suppurativa (HS) is a chronic skin disease of the pilo-sebaceous apocrine unit characterized by significant inflammation and an impaired quality of life. The pathogenesis of HS remains unclear. To determine the HS skin and blood transcriptomes and HS blood proteome, patient data from pr...

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Bibliographic Details
Main Authors: Lauren K Hoffman, Lewis E Tomalin, Gregory Schultz, Michael D Howell, Niroshana Anandasabapathy, Afsaneh Alavi, Mayte Suárez-Fariñas, Michelle A Lowes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6162087?pdf=render

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http://europepmc.org/articles/PMC6162087?pdf=render

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