Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations

Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations

Tumour heterogeneity is well-known; however, studies analysing the progression from primary to metastatic disease are still limited. Here, the authors used phylogenetic analyses and found that for some patients there are multiple seeding events from the primary tumour accompanied by cross-seeding be...

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Bibliographic Details
Main Authors: David Brown, Dominiek Smeets, Borbála Székely, Denis Larsimont, A. Marcell Szász, Pierre-Yves Adnet, Françoise Rothé, Ghizlane Rouas, Zsófia I. Nagy, Zsófia Faragó, Anna-Mária Tőkés, Magdolna Dank, Gyöngyvér Szentmártoni, Nóra Udvarhelyi, Gabriele Zoppoli, Lajos Pusztai, Martine Piccart, Janina Kulka, Diether Lambrechts, Christos Sotiriou, Christine Desmedt
Format: Article
Language:English
Published: Nature Portfolio 2017-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14944

Internet

https://doi.org/10.1038/ncomms14944

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