Roles of the CXCL8-CXCR1/2 Axis in the Tumor Microenvironment and Immunotherapy

Roles of the CXCL8-CXCR1/2 Axis in the Tumor Microenvironment and Immunotherapy

In humans, Interleukin-8 (IL-8 or CXCL8) is a granulocytic chemokine with multiple roles within the tumor microenvironment (TME), such as recruiting immunosuppressive cells to the tumor, increasing tumor angiogenesis, and promoting epithelial-to-mesenchymal transition (EMT). All of these effects of...

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Bibliographic Details
Main Authors: Zhi-Jian Han, Yang-Bing Li, Lu-Xi Yang, Hui-Juan Cheng, Xin Liu, Hao Chen
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Molecules
Subjects:
interleukin-8
chemokine
tumor microenvironment
cancer-associated fibroblast
microbiome
CXC receptors 1 and 2
Online Access:https://www.mdpi.com/1420-3049/27/1/137

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https://www.mdpi.com/1420-3049/27/1/137

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