Discovery of a Novel Antiviral Effect of the Restriction Factor SPOC1 against Human Cytomegalovirus

Discovery of a Novel Antiviral Effect of the Restriction Factor SPOC1 against Human Cytomegalovirus

The chromatin-remodeler SPOC1 (PHF13) is a transcriptional co-regulator and has been identified as a restriction factor against various viruses, including human cytomegalovirus (HCMV). For HCMV, SPOC1 was shown to block the onset of immediate-early (IE) gene expression under low multiplicities of in...

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Bibliographic Details
Main Authors: Anna K. Kuderna, Anna Reichel, Julia Tillmanns, Maja Class, Myriam Scherer, Thomas Stamminger
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Viruses
Subjects:
human cytomegalovirus
restriction factor
viral transcription
antiviral
chromatin remodeler
RNA Pol II
Online Access:https://www.mdpi.com/1999-4915/16/3/363

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https://www.mdpi.com/1999-4915/16/3/363

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