Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse

Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse

Parkinson's disease (PD) is a neurodegenerative disorder classically characterized by the death of dopamine (DA) neurons in the substantia nigra pars compacta and by intracellular Lewy bodies composed largely of α-synuclein. Approximately 5–10% of PD patients have a familial form of Parkinsonis...

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Dettagli Bibliografici
Autori principali: Tonya N. Taylor, Dawid Potgieter, Sabina Anwar, Steven L. Senior, Stephanie Janezic, Sarah Threlfell, Brent Ryan, Laura Parkkinen, Thierry Deltheil, Milena Cioroch, Achilleas Livieratos, Peter L. Oliver, Katie A. Jennings, Kay E. Davies, Olaf Ansorge, David M. Bannerman, Stephanie J. Cragg, Richard Wade-Martins
Natura: Articolo
Lingua:English
Pubblicazione: Elsevier 2014-02-01
Serie:Neurobiology of Disease
Soggetti:
Parkinson's disease
α-Synuclein
Dopamine
Norepinephrine
Voltammetry
Behavior
Accesso online:http://www.sciencedirect.com/science/article/pii/S0969996113002787

Accesso online

http://www.sciencedirect.com/science/article/pii/S0969996113002787

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