Risk factors for graft-versus-host-disease after donor lymphocyte infusion following T-cell depleted allogeneic stem cell transplantation

Risk factors for graft-versus-host-disease after donor lymphocyte infusion following T-cell depleted allogeneic stem cell transplantation

IntroductionUnmodified donor lymphocyte infusions (DLI) after allogeneic stem cell transplantation (alloSCT) can boost the beneficial Graft-versus-Leukemia (GvL) effect but may also induce severe Graft-versus-Host-Disease (GvHD). To improve the balance between GvL and GvHD, it is crucial to identify...

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Bibliographic Details
Main Authors: Eva A. S. Koster, Peter A. von dem Borne, Peter van Balen, Erik W. A. Marijt, Jennifer M. L. Tjon, Tjeerd J. F. Snijders, Daniëlle van Lammeren, Hendrik Veelken, J. H. Frederik Falkenburg, Constantijn J. M. Halkes, Liesbeth C. de Wreede
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
allogeneic stem cell transplantation
donor lymphocyte infusion
graft-versus-host-disease
acute myeloid leukemia
acute lymphoblastic leukemia
myelodysplastic syndrome
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1335341/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1335341/full

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