Fluorine-thiol displacement probes for acetaminophen's hepatotoxicity

Fluorine-thiol displacement probes for acetaminophen's hepatotoxicity

Chemicals possessing reactive electrophiles can denature innate proteins leading to undesired toxicity, and the overdose-induced liver injury by drugs containing electrophiles has been one of the major causes of non-approval and withdraw by the US Food and Drug Administration (FDA). Elucidating the...

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Bibliographic Details
Main Authors: Benjamin L. Prather, Shuyue Ji, Yue Zhao, Femil Joseph Shajan, Mi Zhao, Zakey Yusuf Buuh, Robert Maloney, Rui Zhang, Carson Cohen, Rongsheng E. Wang
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Acetaminophen (APAP)
Liver
Hepatotoxicity
Bioorthogonal
Click chemistry
Fluorine displacement
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383522003380

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http://www.sciencedirect.com/science/article/pii/S2211383522003380

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