Elevated circulating level of β-aminoisobutyric acid (BAIBA) in heart failure patients with type 2 diabetes receiving sodium-glucose cotransporter 2 inhibitors

Elevated circulating level of β-aminoisobutyric acid (BAIBA) in heart failure patients with type 2 diabetes receiving sodium-glucose cotransporter 2 inhibitors

Abstract Aims The mechanism by which a sodium-glucose cotransporter inhibitor (SGLT2i) induces favorable effects on diabetes and cardiovascular diseases including heart failure (HF) remains poorly understood. Metabolomics including amino acid profiling enables detection of alterations in whole body...

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Bibliographic Details
Main Authors: Satoshi Katano, Toshiyuki Yano, Hidemichi Kouzu, Ryohei Nagaoka, Ryo Numazawa, Kotaro Yamano, Yusuke Fujisawa, Katsuhiko Ohori, Nobutaka Nagano, Takefumi Fujito, Ryo Nishikawa, Wataru Ohwada, Masaki Katayose, Tatsuya Sato, Atsushi Kuno, Masato Furuhashi
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Cardiovascular Diabetology
Subjects:
Heart failure
Diabetes mellitus
Amino acid
β-aminoisobutyric acid
Sodium-glucose cotransporter 2 inhibitors
SGLT2
Online Access:https://doi.org/10.1186/s12933-022-01727-x

Internet

https://doi.org/10.1186/s12933-022-01727-x

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