PICALM and Alzheimer’s Disease: An Update and Perspectives

PICALM and Alzheimer’s Disease: An Update and Perspectives

Genome-wide association studies (GWAS) have identified the <i>PICALM</i> (Phosphatidylinositol binding clathrin-assembly protein) gene as the most significant genetic susceptibility locus after <i>APOE</i> and <i>BIN1</i>. PICALM is a clathrin-adaptor protein that...

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Bibliographic Details
Main Authors: Kunie Ando, Siranjeevi Nagaraj, Fahri Küçükali, Marie-Ange de Fisenne, Andreea-Claudia Kosa, Emilie Doeraene, Lidia Lopez Gutierrez, Jean-Pierre Brion, Karelle Leroy
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cells
Subjects:
<i>PICALM</i>
Alzheimer’s disease
GWAS
amyloid β
neurofibrillary tangles
microglia
Online Access:https://www.mdpi.com/2073-4409/11/24/3994

Internet

https://www.mdpi.com/2073-4409/11/24/3994

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