Molecular elucidation of drug-induced abnormal assemblies of the hepatitis B virus capsid protein by solid-state NMR

Molecular elucidation of drug-induced abnormal assemblies of the hepatitis B virus capsid protein by solid-state NMR

Hepatitis B virus (HBV) capsid assembly modulators (CAM) represent a recent class of anti-HBV antivirals. Structural approaches provide limited conformational information on the CAM-induced off-path assemblies. Here, authors use solid-state NMR to establish a structural view on assembly modulation o...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Lauriane Lecoq, Louis Brigandat, Rebecca Huber, Marie-Laure Fogeron, Shishan Wang, Marie Dujardin, Mathilde Briday, Thomas Wiegand, Morgane Callon, Alexander Malär, David Durantel, Dara Burdette, Jan Martin Berke, Beat H. Meier, Michael Nassal, Anja Böckmann
Formatua:	Artikulua
Hizkuntza:	English
Argitaratua:	Nature Portfolio 2023-01-01
Saila:	Nature Communications
Sarrera elektronikoa:	https://doi.org/10.1038/s41467-023-36219-3

Antzeko izenburuak

Combining Cell-Free Protein Synthesis and NMR Into a Tool to Study Capsid Assembly Modulation
nork: Shishan Wang, et al.
Argitaratua: (2019-08-01)

100 kHz MAS Proton-Detected NMR Spectroscopy of Hepatitis B Virus Capsids
nork: Lauriane Lecoq, et al.
Argitaratua: (2019-07-01)

Experimental Characterization of the Hepatitis B Virus Capsid Dynamics by Solid-State NMR
nork: Alexander A. Malär, et al.
Argitaratua: (2022-01-01)

Solid-State NMR for Studying the Structure and Dynamics of Viral Assemblies
nork: Lauriane Lecoq, et al.
Argitaratua: (2020-09-01)

Structural conservation of HBV-like capsid proteins over hundreds of millions of years despite the shift from non-enveloped to enveloped life-style
nork: Sara Pfister, et al.
Argitaratua: (2023-03-01)

NMR side-chain assignments of the Crimean–Congo hemorrhagic fever virus glycoprotein n cytosolic domain
nork: L. Brigandat, et al.
Argitaratua: (2024-07-01)

Phosphorylation and Alternative Translation on Wheat Germ Cell-Free Protein Synthesis of the DHBV Large Envelope Protein
nork: Guillaume David, et al.
Argitaratua: (2019-12-01)

Phosphorylation of the Hepatitis B Virus Large Envelope Protein
nork: Marie-Laure Fogeron, et al.
Argitaratua: (2022-02-01)

Hepatitis B virus core protein phosphorylation: Identification of the SRPK1 target sites and impact of their occupancy on RNA binding and capsid structure.
nork: Julia Heger-Stevic, et al.
Argitaratua: (2018-12-01)

Asparagine and Glutamine Side-Chains and Ladders in HET-s(218–289) Amyloid Fibrils Studied by Fast Magic-Angle Spinning NMR
nork: Thomas Wiegand, et al.
Argitaratua: (2020-09-01)

Slowly folding surface extension in the prototypic avian hepatitis B virus capsid governs stability
nork: Cihan Makbul, et al.
Argitaratua: (2020-08-01)

Whole-Chain Tick Saliva Proteins Presented on Hepatitis B Virus Capsid-Like Particles Induce High-Titered Antibodies with Neutralizing Potential.
nork: Philipp Kolb, et al.
Argitaratua: (2015-01-01)

Crystal Structure of the Full-Length Feline Immunodeficiency Virus Capsid Protein Shows an N-Terminal β-Hairpin in the Absence of N-Terminal Proline
nork: Christelle Folio, et al.
Argitaratua: (2017-11-01)

Le discours de la promesse chez les promoteurs de l’ingénierie climatique
nork: Régis Briday
Argitaratua: (2019-04-01)

The conformational changes coupling ATP hydrolysis and translocation in a bacterial DnaB helicase
nork: Thomas Wiegand, et al.
Argitaratua: (2019-01-01)

High-spin Metal Centres in Dipolar EPR Spectroscopy
nork: Katharina Keller, et al.
Argitaratua: (2018-04-01)

Do NSm Virulence Factors in the <i>Bunyavirales</i> Viral Order Originate from Gn Gene Duplication?
nork: Victor Lefebvre, et al.
Argitaratua: (2024-01-01)

Human hepatitis B virus production in avian cells is characterized by enhanced RNA splicing and the presence of capsids containing shortened genomes.
nork: Josef Köck, et al.
Argitaratua: (2012-01-01)

Fitness costs of mutations at the HIV-1 capsid hexamerization interface.
nork: Siriphan Manocheewa, et al.
Argitaratua: (2013-01-01)

Sedimentation Yields Long-Term Stable Protein Samples as Shown by Solid-State NMR
nork: Thomas Wiegand, et al.
Argitaratua: (2020-02-01)

Alternative salt bridge formation in Aβ – a hallmark of early-onset Alzheimer’s disease?
nork: Maarten eSchledorn, et al.
Argitaratua: (2015-04-01)

Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure
nork: KM Rifat Faysal, et al.
Argitaratua: (2024-02-01)

Including Protons in Solid-State NMR Resonance Assignment and Secondary Structure Analysis: The Example of RNA Polymerase II Subunits Rpo4/7
nork: Anahit Torosyan, et al.
Argitaratua: (2019-10-01)

Nanomedicine and Phage Capsids
nork: Philip Serwer, et al.
Argitaratua: (2018-06-01)

Use of Capsid Integrity-qPCR for Detecting Viral Capsid Integrity in Wastewater
nork: Jessica L. Kevill, et al.
Argitaratua: (2023-12-01)

A Unique Role of the Human Cytomegalovirus Small Capsid Protein in Capsid Assembly
nork: Eva Maria Borst, et al.
Argitaratua: (2022-10-01)

HIV-1 capsid variability: viral exploitation and evasion of capsid-binding molecules
nork: Akatsuki Saito, et al.
Argitaratua: (2021-10-01)

Defining the HIV Capsid Binding Site of Nucleoporin 153
nork: Shunji Li, et al.
Argitaratua: (2022-10-01)

Minor proteins, mobile arms and membrane-capsid interactions in the bacteriophage PRD1 capsid.
nork: San Martín, C, et al.
Argitaratua: (2002)

Atomic structure of the human herpesvirus 6B capsid and capsid-associated tegument complexes
nork: Yibo Zhang, et al.
Argitaratua: (2019-11-01)

ATP Analogues for Structural Investigations: Case Studies of a DnaB Helicase and an ABC Transporter
nork: Denis Lacabanne, et al.
Argitaratua: (2020-11-01)

HIV Capsid and Integration Targeting
nork: Alan N. Engelman
Argitaratua: (2021-01-01)

The Dynamic Life of Virus Capsids
nork: Michael B. Sherman, et al.
Argitaratua: (2020-06-01)

Structures of pseudorabies virus capsids
nork: Guosong Wang, et al.
Argitaratua: (2022-03-01)

The Astrovirus Capsid: A Review
nork: Carlos F. Arias, et al.
Argitaratua: (2017-01-01)

The Dynamic Capsid Structures of the Noroviruses
nork: Hong Q. Smith, et al.
Argitaratua: (2019-03-01)

Purification of Herpesvirus Virions and Capsids
nork: Xinghong Dai, et al.
Argitaratua: (2014-08-01)

Disassembling the Nature of Capsid: Biochemical, Genetic, and Imaging Approaches to Assess HIV-1 Capsid Functions
nork: Zachary Ingram, et al.
Argitaratua: (2021-11-01)

Cryo-electron microscopy structures of capsids and in situ portals of DNA-devoid capsids of human cytomegalovirus
nork: Zhihai Li, et al.
Argitaratua: (2023-04-01)

A kinase chaperones hepatitis B virus capsid assembly and captures capsid dynamics in vitro.
nork: Chao Chen, et al.
Argitaratua: (2011-11-01)