SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer

SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer

Non-small cell lung cancers with inactivating SMARCA4 mutations are currently undruggable. Here, the authors show that the absence of SMARCA4/2 reduces chromatin accessibility at the CCND1 locus, leading to a subsequent reduction in cyclin D1 expression, which promotes vulnerability of these cancers...

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Bibliographic Details
Main Authors: Yibo Xue, Brian Meehan, Zheng Fu, Xue Qing D. Wang, Pierre Olivier Fiset, Ralf Rieker, Cameron Levins, Tim Kong, Xianbing Zhu, Geneviève Morin, Lashanda Skerritt, Esther Herpel, Sriram Venneti, Daniel Martinez, Alexander R. Judkins, Sungmi Jung, Sophie Camilleri-Broet, Anne V. Gonzalez, Marie-Christine Guiot, William W. Lockwood, Jonathan D. Spicer, Abbas Agaimy, William A. Pastor, Josée Dostie, Janusz Rak, William D. Foulkes, Sidong Huang
Format: Article
Language:English
Published: Nature Portfolio 2019-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08380-1

Internet

https://doi.org/10.1038/s41467-019-08380-1

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