Optimized Signal Peptide for Secretory Expression of Human Recombinant Somatropin in E. coli

Optimized Signal Peptide for Secretory Expression of Human Recombinant Somatropin in E. coli

Purpose: The human somatropin is a single-chain polypeptide with a pivotal role in various biological processes. Although Escherichia coli is considered as a preferred host for the production of human somatropin, the high expression of this protein in E. coli results in the accumulation of protein a...

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Bibliographic Details
Main Authors: Zeynab Ahmadi, Safar Farajnia, Davoud Farajzadeh, Naser Pouladi, Neda Pourvatan, Mohammad Karbalaeimahdi, Fahime Shayegh, Maryam Arya
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2023-03-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
human somatropin
signal peptide
e. coli
secretary expression
Online Access:https://apb.tbzmed.ac.ir/PDF/apb-13-339.pdf

Internet

https://apb.tbzmed.ac.ir/PDF/apb-13-339.pdf

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