Optimized Signal Peptide for Secretory Expression of Human Recombinant Somatropin in E. coli
Purpose: The human somatropin is a single-chain polypeptide with a pivotal role in various biological processes. Although Escherichia coli is considered as a preferred host for the production of human somatropin, the high expression of this protein in E. coli results in the accumulation of protein a...
Main Authors: | Zeynab Ahmadi, Safar Farajnia, Davoud Farajzadeh, Naser Pouladi, Neda Pourvatan, Mohammad Karbalaeimahdi, Fahime Shayegh, Maryam Arya |
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Format: | Article |
Language: | English |
Published: |
Tabriz University of Medical Sciences
2023-03-01
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Series: | Advanced Pharmaceutical Bulletin |
Subjects: | |
Online Access: | https://apb.tbzmed.ac.ir/PDF/apb-13-339.pdf |
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