Triamcinolone acetonide-loaded nanoparticles encapsulated by CD90+ MCSs-derived microvesicles drive anti-inflammatory properties and promote cartilage regeneration after osteoarthritis
Highlights Long-term injection of glucocorticoids in the knee joint cavity promotes loss of cartilage content. CD90-positive stem cell vesicles encapsulated with Triamcinolone acetonide-loaded nanoparticles have good materials. T-CD90@NPs drive anti-inflammatory properties and promote cartilage rege...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-03-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-022-01367-z |
| _version_ | 1798041369730613248 |
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| author | Yuanlong Li Qingqiang Tu Dongmei Xie Shurui Chen Kai Gao Xiaochun Xu Ziji Zhang Xifan Mei |
| author_facet | Yuanlong Li Qingqiang Tu Dongmei Xie Shurui Chen Kai Gao Xiaochun Xu Ziji Zhang Xifan Mei |
| author_sort | Yuanlong Li |
| collection | DOAJ |
| description | Highlights Long-term injection of glucocorticoids in the knee joint cavity promotes loss of cartilage content. CD90-positive stem cell vesicles encapsulated with Triamcinolone acetonide-loaded nanoparticles have good materials. T-CD90@NPs drive anti-inflammatory properties and promote cartilage regeneration after osteoarthritis. T-CD90@NPs regulate the polarization of type 2 macrophages to resist inflammation. T-CD90@NPs promote chondrocyte regeneration through the FOXO signaling pathway. |
| first_indexed | 2024-04-11T22:20:35Z |
| format | Article |
| id | doaj.art-f923eeb22f264492a43c3ba978491da3 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-11T22:20:35Z |
| publishDate | 2022-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-f923eeb22f264492a43c3ba978491da32022-12-22T04:00:10ZengBMCJournal of Nanobiotechnology1477-31552022-03-0120112010.1186/s12951-022-01367-zTriamcinolone acetonide-loaded nanoparticles encapsulated by CD90+ MCSs-derived microvesicles drive anti-inflammatory properties and promote cartilage regeneration after osteoarthritisYuanlong Li0Qingqiang Tu1Dongmei Xie2Shurui Chen3Kai Gao4Xiaochun Xu5Ziji Zhang6Xifan Mei7Department of Orthopedics, The First Affiliated Hospital of Jinzhou Medical UniversityDepartment of Orthopedics, The First Affiliated Hospital, Sun Yat-Sen UniversityThe Third Affiliated Hospital, Sun Yat-Sen UniversityDepartment of Orthopedics, The First Affiliated Hospital of Jinzhou Medical UniversityDepartment of Orthopedics, The First Affiliated Hospital of Jinzhou Medical UniversityThe Third Affiliated Hospital, Sun Yat-Sen UniversityDepartment of Orthopedics, The First Affiliated Hospital, Sun Yat-Sen UniversityDepartment of Orthopedics, The First Affiliated Hospital of Jinzhou Medical UniversityHighlights Long-term injection of glucocorticoids in the knee joint cavity promotes loss of cartilage content. CD90-positive stem cell vesicles encapsulated with Triamcinolone acetonide-loaded nanoparticles have good materials. T-CD90@NPs drive anti-inflammatory properties and promote cartilage regeneration after osteoarthritis. T-CD90@NPs regulate the polarization of type 2 macrophages to resist inflammation. T-CD90@NPs promote chondrocyte regeneration through the FOXO signaling pathway.https://doi.org/10.1186/s12951-022-01367-zOsteoarthritisBiomimetic nanoparticlesCD90+ MCSs-derived micro-vesicleCartilage regenerationAnti-inflammatory |
| spellingShingle | Yuanlong Li Qingqiang Tu Dongmei Xie Shurui Chen Kai Gao Xiaochun Xu Ziji Zhang Xifan Mei Triamcinolone acetonide-loaded nanoparticles encapsulated by CD90+ MCSs-derived microvesicles drive anti-inflammatory properties and promote cartilage regeneration after osteoarthritis Journal of Nanobiotechnology Osteoarthritis Biomimetic nanoparticles CD90+ MCSs-derived micro-vesicle Cartilage regeneration Anti-inflammatory |
| title | Triamcinolone acetonide-loaded nanoparticles encapsulated by CD90+ MCSs-derived microvesicles drive anti-inflammatory properties and promote cartilage regeneration after osteoarthritis |
| title_full | Triamcinolone acetonide-loaded nanoparticles encapsulated by CD90+ MCSs-derived microvesicles drive anti-inflammatory properties and promote cartilage regeneration after osteoarthritis |
| title_fullStr | Triamcinolone acetonide-loaded nanoparticles encapsulated by CD90+ MCSs-derived microvesicles drive anti-inflammatory properties and promote cartilage regeneration after osteoarthritis |
| title_full_unstemmed | Triamcinolone acetonide-loaded nanoparticles encapsulated by CD90+ MCSs-derived microvesicles drive anti-inflammatory properties and promote cartilage regeneration after osteoarthritis |
| title_short | Triamcinolone acetonide-loaded nanoparticles encapsulated by CD90+ MCSs-derived microvesicles drive anti-inflammatory properties and promote cartilage regeneration after osteoarthritis |
| title_sort | triamcinolone acetonide loaded nanoparticles encapsulated by cd90 mcss derived microvesicles drive anti inflammatory properties and promote cartilage regeneration after osteoarthritis |
| topic | Osteoarthritis Biomimetic nanoparticles CD90+ MCSs-derived micro-vesicle Cartilage regeneration Anti-inflammatory |
| url | https://doi.org/10.1186/s12951-022-01367-z |
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