Sorafenib inhibits ossification of the posterior longitudinal ligament by blocking LOXL2-mediated vascularization

Sorafenib inhibits ossification of the posterior longitudinal ligament by blocking LOXL2-mediated vascularization

Abstract Ossification of the Posterior Longitudinal Ligament (OPLL) is a degenerative hyperostosis disease characterized by the transformation of the soft and elastic vertebral ligament into bone, resulting in limited spinal mobility and nerve compression. Employing both bulk and single-cell RNA seq...

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Bibliographic Details
Main Authors: Longqing Wang, Wenhao Jiang, Siyuan Zhao, Dong Xie, Qing Chen, Qi Zhao, Hao Wu, Jian Luo, Lili Yang
Format: Article
Language:English
Published: Nature Publishing Group 2024-04-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-024-00327-7

Internet

https://doi.org/10.1038/s41413-024-00327-7

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