Lung Micrometastases Display ECM Depletion and Softening While Macrometastases Are 30-Fold Stiffer and Enriched in Fibronectin

Lung Micrometastases Display ECM Depletion and Softening While Macrometastases Are 30-Fold Stiffer and Enriched in Fibronectin

Mechanical changes in tumors have long been linked to increased malignancy and therapy resistance and attributed to mechanical changes in the tumor extracellular matrix (ECM). However, to the best of our knowledge, there have been no mechanical studies on decellularized tumors. Here, we studied the...

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Bibliographic Details
Main Authors: Maria Narciso, África Martínez, Constança Júnior, Natalia Díaz-Valdivia, Anna Ulldemolins, Massimiliano Berardi, Kate Neal, Daniel Navajas, Ramon Farré, Jordi Alcaraz, Isaac Almendros, Núria Gavara
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cancers
Subjects:
lung metastases
melanoma
lung carcinoma
extracellular matrix
decellularization
atomic force microscopy
Online Access:https://www.mdpi.com/2072-6694/15/8/2404

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https://www.mdpi.com/2072-6694/15/8/2404

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