Mequindox Induced Genotoxicity and Carcinogenicity in Mice

Mequindox Induced Genotoxicity and Carcinogenicity in Mice

Mequindox (MEQ), acting as an inhibitor of deoxyribonucleic acid (DNA) synthesis, is a synthetic heterocyclic N-oxides. To investigate the potential carcinogenicity of MEQ, four groups of Kun-Ming (KM) mice (50 mice/sex/group) were fed with diets containing MEQ (0, 25, 55, and 110 mg/kg) for one and...

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Bibliographic Details
Main Authors: Qianying Liu, Zhixin Lei, Qin Wu, Deyu Huang, Shuyu Xie, Xu Wang, Yuanhu Pan, Zonghui Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Pharmacology
Subjects:
mequindox
quinoxaline
carcinogenicity
genotoxicity
KM mice
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00361/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00361/full

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