A single-dose, open-label, randomized, scintigraphic study to investigate the gastrointestinal behavior of 2 triple-combination cold products (acetaminophen, phenylephrine, and dextromethorphan) in healthy male volunteers

A single-dose, open-label, randomized, scintigraphic study to investigate the gastrointestinal behavior of 2 triple-combination cold products (acetaminophen, phenylephrine, and dextromethorphan) in healthy male volunteers

Abstract Background Common cold symptoms may be mitigated by products in caplet, nasal spray, and oral solution formulations, although variations exist in the bioavailability of the active ingredients contained within these products. Rapid gastric emptying (GE) of these active ingredients is importa...

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Bibliographic Details
Main Authors: Pascal Mallefet, Marianna Armogida, Walter J. Doll, Richard C. Page, Erik P. Sandefer
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Trials
Subjects:
Common cold
Gastric emptying
Radionuclide imaging
Powders
Beverages
Duodenum
Online Access:https://doi.org/10.1186/s13063-022-06037-x

Internet

https://doi.org/10.1186/s13063-022-06037-x

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