Estrogen receptors α, β and GPER in the CNS and trigeminal system - molecular and functional aspects

Abstract Background Migraine occurs 2–3 times more often in females than in males and is in many females associated with the onset of menstruation. The steroid hormone, 17β-estradiol (estrogen, E2), exerts its effects by binding and activating several estrogen receptors (ERs). Calcitonin gene-relate...

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Bibliographic Details
Main Authors: Karin Warfvinge, Diana N. Krause, Aida Maddahi, Jacob C. A. Edvinsson, Lars Edvinsson, Kristian A. Haanes
Format: Article
Language:English
Published: BMC 2020-11-01
Series:The Journal of Headache and Pain
Subjects:
Online Access:http://link.springer.com/article/10.1186/s10194-020-01197-0