The Crystal Structure of <i>N</i>-(1-Arylethyl)-4-methyl- 2,2-dioxo-1<i>H</i>-2λ<sup>6</sup>,1-benzothiazine-3-carboxamides as the Factor Determining Biological Activity Thereof

The Crystal Structure of <i>N</i>-(1-Arylethyl)-4-methyl- 2,2-dioxo-1<i>H</i>-2λ<sup>6</sup>,1-benzothiazine-3-carboxamides as the Factor Determining Biological Activity Thereof

In order to detect new structural and biological patterns in a series of hetaryl-3-carboxylic acid derivatives, the optically pure <i>(S)-</i> and <i>(R)-</i>enantiomers of <i>N-</i>(1-arylethyl)-4-methyl- 2,2-dioxo-1<i>H-</i>2&#955;<sup>6<...

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Bibliographic Details
Main Authors: Igor V. Ukrainets, Ganna M. Hamza, Anna A. Burian, Natali I. Voloshchuk, Oxana V. Malchenko, Svitlana V. Shishkina, Irina A. Danylova, Galina Sim
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Scientia Pharmaceutica
Subjects:
4-methyl-2,2-dioxo-1<i>H</i>-2λ<sup>6</sup>,1-benzothiazine-3-carboxylamide
2,1-benzothiazine
chiral switches, crystal structure
molecular conformation
analgesic activity
anti-inflammatory action
Online Access:https://www.mdpi.com/2218-0532/87/2/10

Internet

https://www.mdpi.com/2218-0532/87/2/10

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