Par1b induces asymmetric inheritance of plasma membrane domains via LGN-dependent mitotic spindle orientation in proliferating hepatocytes.

Par1b induces asymmetric inheritance of plasma membrane domains via LGN-dependent mitotic spindle orientation in proliferating hepatocytes.

The development and maintenance of polarized epithelial tissue requires a tightly controlled orientation of mitotic cell division relative to the apical polarity axis. Hepatocytes display a unique polarized architecture. We demonstrate that mitotic hepatocytes asymmetrically segregate their apical p...

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Bibliographic Details
Main Authors: Christiaan L Slim, Francisco Lázaro-Diéguez, Marjolein Bijlard, Mathilda J M Toussaint, Alain de Bruin, Quansheng Du, Anne Müsch, Sven C D van Ijzendoorn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-12-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC3866089?pdf=render

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http://europepmc.org/articles/PMC3866089?pdf=render

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