Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals

Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals

Abstract Herein, we studied the impact of empty LNP (eLNP), component of mRNA-based vaccine, on anti-viral pathways and immune function of cells from young and aged individuals. eLNP induced maturation of monocyte derived dendritic cells (MDDCs). We further show that eLNP upregulated CD40 and induce...

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Bibliographic Details
Main Authors: Jennifer Connors, David Joyner, Nathan J. Mege, Gina M. Cusimano, Matthew R. Bell, Jennifer Marcy, Bhavani Taramangalam, Kenneth M. Kim, Paulo J. C. Lin, Ying K. Tam, Drew Weissman, Michele A. Kutzler, Mohamad-Gabriel Alameh, Elias K. Haddad
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-04555-1

Internet

https://doi.org/10.1038/s42003-023-04555-1

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