Fast bacterial growth reduces antibiotic accumulation and efficacy

Fast bacterial growth reduces antibiotic accumulation and efficacy

Phenotypic variations between individual microbial cells play a key role in the resistance of microbial pathogens to pharmacotherapies. Nevertheless, little is known about cell individuality in antibiotic accumulation. Here, we hypothesise that phenotypic diversification can be driven by fundamental...

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Bibliographic Details
Main Authors: Urszula Łapińska, Margaritis Voliotis, Ka Kiu Lee, Adrian Campey, M Rhia L Stone, Brandon Tuck, Wanida Phetsang, Bing Zhang, Krasimira Tsaneva-Atanasova, Mark AT Blaskovich, Stefano Pagliara
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-06-01
Series:eLife
Subjects:
membrane transport
antibiotics
single-cell analysis
antibiotic resistance
phenotypic heterogeneity
antibiotic uptake
Online Access:https://elifesciences.org/articles/74062

Internet

https://elifesciences.org/articles/74062

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